2016 Fiscal Year Final Research Report
Mechanism for regulation of bacterial genes to escape from phagocytosis for persistent infection in host
Project/Area Number |
26440049
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Functional biochemistry
|
Research Institution | Kanazawa University |
Principal Investigator |
|
Project Period (FY) |
2014-04-01 – 2017-03-31
|
Keywords | 自然免疫 / 細菌 / 細胞貪食 / 遺伝子発現 / 感染症 |
Outline of Final Research Achievements |
Bacteria under hostile environmental conditions alter their gene expression to adapt and survive in the host. This study identified genes in Escherichia coli that acted for regulation of virulence in host with aid of the two-component regulatory system EnvZ-OmpR. Among sigma factors, we reported that RpoS, a type of RNA polymerase sigma factors in E. coli, induced expression of bacterial catalases for inhibition of phagocytic killing in host. In this study, we found that RpoS raised in host in a manner of post-transcriptional regulation for persistence in host.
|
Free Research Field |
生化学
|