Comparative study for gastrointestinal motor stimulating actions of ghrelin and motilin

2016 Fiscal Year Final Research Report

• Project/Area Number: 26440169
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Morphology/Structure
• Research Institution: Rakuno Gakuen University
• Principal Investigator: KITAZAWA Takio 酪農学園大学, 獣医学群, 教授 (50146338)
• Co-Investigator(Renkei-kenkyūsha): Sakai Takafumi 埼玉大学, 理工学研究科, 教授 (40235114)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: グレリン / モチリン / 消化管 / 収縮作用 / 脊椎動物 / グレリン受容体 / モチリン受容体

Outline of Final Research Achievements

Ghrelin and motilin are gut peptides that regulate the gastrointestinal motility of mammals and birds. The aim of this study is to clarify the function of motilin/ghrelin on gastrointestinal contractility of amphibians and fish using isolated muscle strips. Homologous ghrelin did not change the contractility of amphibians (bullfrog and Japanese fire belly newt) and fish (zebrafish) gastrointestinal tract, suggesting that the motor stimulating action of ghrelin is not conserved across vertebrates. On the other hand, motilin-mediated gastrointestinal motor regulating system is possible to present in the bullfrog and zebrafish but its physiological significance should be studied in future.

Free Research Field

消化管薬理学