Mode of action of thyroid hormone in brain to open the sensitive period for learning

2016 Fiscal Year Final Research Report

• Project/Area Number: 26440182
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Animal physiology/Animal behavior
• Research Institution: Teikyo University
• Principal Investigator: Homma Koichi 帝京大学, 薬学部, 教授 (90251438)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 神経科学 / 脳・神経 / 行動学 / 薬学 / 動物 / 刷り込み / 学習感臨界期 / ニワトリ

Outline of Final Research Achievements

The purpose of this study is to reveal the mode of action of thyroid hormone in brain to open the sensitive period for learning of filial imprinting. We found that acute protein phosphorylation cascade occurred in response to the inflow of thyroid hormone at an early phase of learning. As a result, intracellular cytoskeletal organization and the electrophysiological changes were induced and then the memory information was stored in the novel brain region we identified recently.

Free Research Field

脳神経科学