• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to project page

2017 Fiscal Year Final Research Report

Mechanism and biological significance of glucose inactivation of transporters in yeast

Research Project

  • PDF
Project/Area Number 26450084
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Applied microbiology
Research InstitutionTohoku University

Principal Investigator

Shintani Takahiro  東北大学, 農学研究科, 准教授 (70374973)

Co-Investigator(Renkei-kenkyūsha) GOMI Katsuya  東北大学, 大学院農学研究科, 教授 (60302197)
Research Collaborator FUJITA Shoki  
TAKEKOSHI Yutaro  
Project Period (FY) 2014-04-01 – 2018-03-31
Keywords酵母 / モノカルボン酸輸送体 / グルコース不活性化 / エンドサイトーシス
Outline of Final Research Achievements

Yeast is a microbe that contributes to bread making and alcohol fermentation. Incorporation of lactic acid and pyruvate by yeast is inhibited in a medium containing glucose. This phenomenon is partly due to glucose-induced endocytic degradation, so-called as glucose inactivation, of Jen1. It is known that glucose inactivation of Jen1 is triggered by its ubiquitination by Rsp5-Rod1 ubiquitin ligase complex. We discovered that the C-terminal 20-amino-acid region of Jen1 recognized by Rsp5-Rod1 complex and sufficient to induce glucose inactivation of transmembrane transporter.

Free Research Field

応用微生物学

URL: 

Published: 2019-03-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi