Effects of marginal zinc deficiency on psychological development and mood disorder in growing rats.

2016 Fiscal Year Final Research Report

• Project/Area Number: 26450149
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Food science
• Research Institution: Tohoku University
• Principal Investigator: GOTO TOMOKO 東北大学, 農学研究科, 助教 (00342783)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 潜在的亜鉛欠乏 / ラット / 精神発達 / 気分障害

Outline of Final Research Achievements

It has been reported that some of depression symptom shows decreased serum zinc concentration, serotonin secretion. In order to investigate the effects of marginal zinc deficiency on psychological development and mood disorder in growing rats, we monitored the locomotive activity and secretion of norepinephrine and serotonin from brain. We found that locomotive activity of zinc-deficient rats during the dark period significantly decrease after 12 days of feeding. It suggests that decreased locomotive activity might be associated with depression symptom. On day 4, secretion of norepinephrine and serotonin from lateral hypothalamus of zinc-deficient rats decreased compared with control rats.

Free Research Field

農学