2016 Fiscal Year Final Research Report
Functional regulation of canine adipocytes through TGF-beta family signaling
| Project/Area Number |
26450442
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Integrative animal science
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| Research Institution | Kyoto University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
MURAKAMI Masaru 麻布大学, 獣医学部, 教授 (80271360)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 脂肪細胞 / イヌ / TGF-βファミリー |
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| Outline of Final Research Achievements |
We evaluated SNPs on ALK3 and ALK7 genes using a total of 55 dogs of various breeds, which have been shown to relate to obesity in humans; no SNPs were detected. Treatment with TGF-β1, activin A, activin B, BMP4 or BMP7 increased expression level of adipose triglyceride lipase. TGF-β family affected cellular content of free amino acids in adipocytes. Especially, insulin-induced decrease in cellular content of arginine, glutamic acid and phenylalanine was exaggerated by TGF-β1, activin A and activin B.
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| Free Research Field |
分子栄養学
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