2016 Fiscal Year Final Research Report
Development of novel reactivitity of methylene acetals and its application to synthesis of heterocycles
| Project/Area Number |
26460023
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Chemical pharmacy
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| Research Institution | Kindai University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | メチレンアセタール / エポキシド / N,O-アセタール |
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| Outline of Final Research Achievements |
We developed a novel transformation reaction of methylene acetal using Phenylthiotrimethylsilane and N-bromosuccinimide. The reaction proceeded under mild conditions to afford the corresponding bromoformates, which could be converted to the corresponding epoxides by the treatment of NaOMe. This reaction was applicable to one-pot transformation from methylene acetal to eppoxide. The methylene acetal derived from aminoalcohol was also transformed under the same conditions giving the corresponding product.
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| Free Research Field |
有機合成化学
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