2016 Fiscal Year Final Research Report
Development of next-generation transdermal dosage form of teriparatide using a self-dissolving microneedles
| Project/Area Number |
26460052
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Physical pharmacy
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| Research Institution | Kyoto Pharmaceutical University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 経皮吸収 / テリパラチド / マイクロニードル / 吸収改善 / 骨粗鬆症 |
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| Outline of Final Research Achievements |
In this study, we prepared a self-dissolving microneedle arrays (MN) containing teriparatide (hPTH), a novel drug for the treatment of osteoporosis to improve the transdermal absorption of hPTH. In the release studies, the release of hPTH from MN was very rapid and almost 100% of drug was released from MN within 5 min. In addition, a rapid increase in the plasma concentration of hPTH was observed after the application of hPTH-MN to the skin. Furthermore,hPTH-MN has pharmacological effect for the treatment of osteoporosis in animal model. Finally, it was found that after the application of hPTH-MN to the skin, the transepidermal water loss (TEWL) value slightly increased, but was recovered to the control level, suggesting the safety of hPTH-MN. These findings indicated that the application of hPTH-MN to the skin is a very effective and safe administration method for the treatment of osteoporosis.
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| Free Research Field |
薬剤学
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