2016 Fiscal Year Final Research Report
Development of treatment agents against ulcerative colitis from medicinal flowers
| Project/Area Number |
26460135
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Natural medicines
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| Research Institution | Kyoto Pharmaceutical University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | メディシナルフラワー / 潰瘍性大腸炎 / 好中球 / 脱顆粒抑制作用 / 一酸化窒素産生抑制作用 / キンモクセイ花部 / トリテルペン / カフェ酸誘導体 |
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| Outline of Final Research Achievements |
We have researched effective compounds against ulcerative colitis from medicinal flowers. As the research results, over 150 constituents were isolated from the flowers of Osmanthus fragrans var. aurantiacus, Camellia sasanqua, Camellia sinensis var. assamica, daylily (Hemerocallis fulva var. kwanso, H. flava, H. minor), Paeonia suffruticosa, Paeonia lactiflora, Dendrobium pharaenopsis. Among them, triterpenes and caffeic acid derivatives significantly showed show the anti-degranulation effects from neutorophil-like cells and the inhibitory effects on NO production, and the information about their structure-activity relationships were obtained. In addition, we could clarify a part of the mechanism of actions of the triterpenes.
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| Free Research Field |
天然物化学、生薬学
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