2016 Fiscal Year Final Research Report
1.Pharmacokinetic and pharmacodynamic analysis of anticoagulants in patients with total knee arthroplasty
| Project/Area Number |
26460237
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Medical pharmacy
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| Research Institution | Meiji Pharmaceutical University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 個別投与 / 抗凝固薬 / 血栓予防 / 体内動態 / 個人差 |
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| Outline of Final Research Achievements |
This study investigated to clarify the factors affecting the efficacy, adverse events, and pharmacokinetics of anti-coagulants, enoxaparin, fondaparinux and edoxaban in Japanese patients undergoing artificial total knee replacement surgery. We have revealed that the maximum plasma concentration of anti-coagulant may be a risk factor for subcutaneous hemorrhage and withdrawal of anti-coagulant. Population pharmacokinetic analysis showed that total clearance and volume of distribution of fondaparinux are affected by creatinine clearance and body weight, respectively.
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| Free Research Field |
薬物動態学
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