Fucosylation regulates reproduction system development.

2016 Fiscal Year Final Research Report

• Project/Area Number: 26460269
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: General anatomy (including histology/embryology)
• Research Institution: Chiba University
• Principal Investigator: BABA Atsushi 千葉大学, 大学院医学研究院, 助教 (70405215)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 器官形成 / 糖鎖修飾 / フコシル化 / 発生・分化 / 細胞・組織 / 管腔様構造

Outline of Final Research Achievements

Developmental defect in the formation of tubular-like structure, is the relatively common desease in human, but its cause remains unknown. Celsr1 inactivation leads to anatomic block of tublar-like structure in reproductive system, and those phenotypes are mimicked in mice with inactivation of Lunatic fringe, which encodes an O-fucose-Nacetylglucosaminyltransferase. Two EGF-like motifs in Celsr1 are O-fucosylated and subject to Fringe modification. Mutation of O-fucosylation sites hampers decreases cell surface expression of the full length protein. Thus, post-transcriptional glycosylation regulates subcellular localization of Celsr1 protein, and participates in the formation of tubular-like structure.

Free Research Field

発生生物学