2016 Fiscal Year Final Research Report
Verifying the regulation of reproductive physiology by kisspeptin through thyroliberin.
| Project/Area Number |
26460316
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Environmental physiology(including physical medicine and nutritional physiology)
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| Research Institution | Nippon Medical School (2015-2016)
Gunma University (2014) |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | kisspeptin / neurokinin B / prolactin / thyroliberin / sex hormone / network / receptor expression / hypothalamus |
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| Outline of Final Research Achievements |
Kisspeptin expressing neuron in the hypothalamus of the brain, is recently well known as a center of rhythm formation in sex hormone cycle. In the present study, we identified a neural network that may convey an effect of kisspeptin to prolactin regulating dopaminergic neuron or thyroliberin producing neuron, which is called TRH neuron, that also regulates body temperature. The finding suggests a possibility that kisspeptin affect via TRH, to the changes of prolactin secretion or body temperature that occur during pregnancy, delivery, or menopause.
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| Free Research Field |
神経内分泌、神経解剖学
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