Blood flow regulatio in vertebral artery.

2016 Fiscal Year Final Research Report

• Project/Area Number: 26460324
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Environmental physiology(including physical medicine and nutritional physiology)
• Research Institution: Japan Women's College of Physical Education
• Principal Investigator: SATO Kohei 日本女子体育大学, 体育学部, 准教授 (00409278)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 椎骨動脈 / 低形成 / 不活動 / 脳血流調節 / 姿勢変化

Outline of Final Research Achievements

Recent studies have suggested that vertebral artery (VA) hypoplasia is a predisposing factor for posterior cerebral stroke. We examined whether anatomical vertebrobasilar ischemia, i.e., unilateral VA hypoplasia and insufficiency, impairs dynamic blood flow regulation. Twenty-eight female subjects were divided into three groups by defined criteria: 1) unilateral VA hypoplasia (N = 8), 2) VA insufficiency (N = 6), and 3) control (N = 14). We evaluated left, right, and net VA blood flows by ultrasonography during hypercapnia, normocapnia, and hypocapnia to evaluate VA CO2 reactivity. In this tudy, VA hypoplasia reduced CO2 reactivity, although non-hypoplastic VA may compensate this regulatory limitation. In subjects with VA insufficiency, lowered CO2 reactivity at the both VA could not preserve normal net VA CO2 reactivity. Our findings provide important information regarding anatomical risk for stroke and ischemia in posterior cerebral circulation.

Free Research Field

環境生理学