Mechanism for microglia involvement of the brain higher function

2016 Fiscal Year Final Research Report

• Project/Area Number: 26460325
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Environmental physiology(including physical medicine and nutritional physiology)
• Research Institution: St. Marianna University School of Medicine
• Principal Investigator: Akema Tatsuo 聖マリアンナ医科大学, 医学部, 名誉教授 (60128585)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: ミクログリア / 海馬 / 学習 / シナプス / 行動解析

Outline of Final Research Achievements

Microglia specific inhibitor, minocycline was administered before and after passive avoidance task in male rats. As the results, minocycline injection shortened the time enter the dark box. This means that the blocking of microglia activation attenuated the establishment of bad memory formation. We also analyzed AMPA receptor subunit expression. We revealed that phosphorylation status of 845 serine thus PKA might be changed. Next, we examined this task in mice. In mice, minocycline injection might attenuate the reconsolidation process hereby long-term bad memory formation was attenuated.

Free Research Field

生理学