The role of Nrf2 in oxidative stress-mediated insulin resistance

2016 Fiscal Year Final Research Report

• Project/Area Number: 26460383
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Pathological medical chemistry
• Research Institution: Tohoku University
• Principal Investigator: Akira Uruno 東北大学, 医学系研究科, 講師 (90396474)
• Co-Investigator(Renkei-kenkyūsha): YAMAMOTO MASAYUKI 東北大学, 大学院医学系研究科, 教授 (50166823)
• Research Collaborator: YAGISHITA YOKO 東北大学, 大学院医学系研究科, 研究員 (50733838)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 糖尿病 / 肥満 / 酸化ストレス / Nrf2 / セレノシステイン

Outline of Final Research Achievements

The numbers of type 2 diabetes mellitus patients are increasing due to the change of life pattern. As it is important to clarify the parthenogenesis of diabetes mellitus, we tried to clarify it.
We generated conditional knockout mice of selenocysteine transfer RNA (Trsp) gene by using rat insulin promoter Cre (TrspRIPKO). The TrspRIP KO mice displayed increments of oxidative stress in hypothalamus.We also found that the mice displayed insulin and leptin resistance to develop obesity and diabetes mellitus. Obesity and diabetes mellitus due to oxidative stress were diminished by activation of Nrf2 signaling in hypothalamus.These results indicate that Nrf2 is a promising target for treatment and prevention of obesity and diabetes mellitus.

Free Research Field

病態生化学