2016 Fiscal Year Final Research Report
Identification of driver genes in inflammation-related intestinal tract carcinogenesis
| Project/Area Number |
26460472
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Experimental pathology
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| Research Institution | Tottori University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 炎症発癌 / 慢性炎症 / ドライバー遺伝子 |
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| Outline of Final Research Achievements |
I tried to determine driver genes in inflammation-related intestinal tract carcinogenesis by using three-dimentional tissue culture system. Solid surface foreign-body such as plastic plate was used to induce inflammation. Reconstitive intestinal tract obtained from K-ras mutant mice formed dormant tumors under chronic inflammation in mice. Intestinal tissue obtained from p53-/- mice developed lethal tumors under chronic inflammation; however, the tissue spontaneously regressed under acute inflammation. Moreover, intestinal tissue obtained from p53+/- mice does not form tumors in the chronic inflammatory environment. I found that p53 gene mutation has a role in the development of inflammation-related intestinal carcinogenesis.
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| Free Research Field |
実験病理学
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