Screening of T. cruzi trans-sialidase inhibitors for a therapeutic agent of Chagas disease

2017 Fiscal Year Final Research Report

• Project/Area Number: 26460508
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Parasitology (including sanitary zoology)
• Research Institution: Nagasaki University
• Principal Investigator: UEMURA Haruki 長崎大学, 熱帯医学研究所, 講師 (60184975)
• Project Period (FY): 2014-04-01 – 2018-03-31
• Keywords: トランスシアリダーゼ / 阻害剤 / シャーガス病 / トリパノソーマ

Outline of Final Research Achievements

Trans-sialidase of Trypanosoma cruzi has been shown as an important key factor of T. cruzi in Chagas’ disease. In this research, we have obtained some trans-sialidase inhibitor molecules from the first random screening of 9,600 core chemical compound library of open innovation center for drug discovery, The University of Tokyo, and further analysis of the derivatives based on the positive compounds at the first screening. No effective inhibitors enough for functional analysis have been reported yet and we are currently engaged in experiments with the new trans-sialidase inhibitors how trans-sialidase influences the parasite process of infection to and development in the host cells. We believe the inhibitor is a key for a new therapeutic agent of Chagas’ disease.

Free Research Field

原虫の生化学