Visualization of immune responses against merozoites malaria infection

2016 Fiscal Year Final Research Report

• Project/Area Number: 26460512
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Parasitology (including sanitary zoology)
• Research Institution: University of the Ryukyus
• Principal Investigator: KISHIMOTO Hidehiro 琉球大学, 医学(系)研究科(研究院), 教授 (80251213)
• Co-Investigator(Renkei-kenkyūsha): KUBO Masato 東京理科大学, 生命医科学研究所, 教授 (40277281) ; WATANABE Hisami 新潟大学, 国際感染症教育研究センター, 特任教授 (50143756)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: マラリア感染防御 / 免疫応答 / T細胞

Outline of Final Research Achievements

In this study, we investigated two questions; first, where dose immune-responses against to erythroid type malaria infection occur. Second, where establised memory T cells specific for the erythroid type malaria are mainteined. To visualize above questions, IFNγ-VENUS transgenic mice were infected with erythroid type malaria and analysed at various time points. Within 7 days, strong T cell response to erythroid type malaria is observed in the spleen whereas there is little immune responses found in other tissue i.e. lymphnodes, bonemarrows, liver. More than 60 days after infection, IFNγ-VENUS positive T cells are found in the spleen. These results indicated that the main tissue, in which immune-responses against to erythroid type malaria infection occur, revealed the spleen.

Free Research Field

免疫学