Clinical significance of serum autotaxin (ATX) and phosphatidylserine-specific phospholipase A1 (PS-PLA1) levels in human kidney disease

2016 Fiscal Year Final Research Report

• Project/Area Number: 26460644
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Laboratory medicine
• Research Institution: Kanazawa University
• Principal Investigator: SHIMIZU MIHO 金沢大学, 保健管理センター, 助教 (10547136)
• Co-Investigator(Renkei-kenkyūsha): YATOMI Yutaka 東京大学, 医学(系)研究科(研究院), 教授 (60200523)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 糖尿病性腎症 / オートタキシン

Outline of Final Research Achievements

We evaluated the relationships between the serum autotaxin (ATX) levels and the clinical and pathological parameters, as well as the long-term renal outcome, in type 2 diabetic patients with biopsy-proven diabetic nephropathy. In this retrospective study, serum samples were collected from 38 Japanese type 2 diabetic patients with biopsy-proven diabetic nephropathy at the time of renal biopsy. A multivariate linear regression analysis revealed the urinary protein excretion to be independently associated with the serum ATX levels. In addition, patients with serum ATX levels above the median showed more advanced diffuse lesions, nodular lesions and arteriolar hyalinosis compared to those with serum ATX levels below the median. However, high serum ATX levels were not associated with renal composite events (need for dialysis or a 50% decline in the estimated glomerular filtration rate from baseline). Parts of this study were published in the Internal Medicine (2016; 55: 215-221).

Free Research Field

腎臓内科学