2017 Fiscal Year Final Research Report
Reguration mechanism of a new gene HMGA2 in thyroid tumors
| Project/Area Number |
26460653
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Laboratory medicine
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| Research Institution | Dokkyo Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
小飼 貴彦 獨協医科大学, 医学部, 准教授 (40711693)
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| Project Period (FY) |
2014-04-01 – 2018-03-31
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| Keywords | HMGA2 / 甲状腺癌 / 甲状腺濾胞癌 / 病理診断 / トランスクリプトーム |
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| Outline of Final Research Achievements |
Recent studies have drawn attention to a nuclear protein HMGA2, abundantly expressed in the mesenchyme, as a differentiation marker in epithelial tumor cells. In this study, we demonstrated selective expression of HMGA2 in malignant tumor tissues, among various types of thyroid tissue, by using immuno-histochemical staining (IHC). Our results raised a possibility that the IHC of HMGA2 in surgical specimens of follicular thyroid cancer brings about more reliable diagnosis, differentiated from benign follicular adenoma, as well as prediction of its prognosis. In addition, our transcriptome analysis in thyroid cancer cell lines supported our hypothesis that pathogenic variants of thyroglobulin promote tumor development through the induction of HMGA2 followed by several oncogenic gene expressions.
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| Free Research Field |
臨床検査医学
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