Cancer diagnosis by analysis of circulating tumor cells with high telomerase activity and cell-free DNA

2016 Fiscal Year Final Research Report

• Project/Area Number: 26460688
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Laboratory medicine
• Research Institution: Showa University
• Principal Investigator: Ito Hiroaki 昭和大学, 医学部, 准教授 (70443447)
• Co-Investigator(Renkei-kenkyūsha): Haruhiro Inoue 昭和大学, 医学部, 教授 (90280966) ; Satoshi Kimura 昭和大学, 医学部, 教授 (30255765)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: がん診断 / 循環がん細胞 / 遊離核酸

Outline of Final Research Achievements

In Japan, the majority of causes of death is cancer. Early detection and rapid start of treatment are very important for improving cancer prognosis. However, there is an excellent system of cancer screening in Japan, we tried to detect circulating tumor cells and cell-free nucleic acids related to cancer in the blood for the purpose of further improving the accuracy of cancer diagnosis.
By using Raman scattering spectroscopy, it is possible to detect more cell-free nucleic acids and proteins related to cancer in the blood from the patients with gastric or colonic cancer than the patients without cancer.
Moreover, applying this spectroscopic method, we established the basic technology for evaluating cell biology without labeling.

Free Research Field

腫瘍外科学