2016 Fiscal Year Final Research Report
Measurement of trace elements with micro-PIXE method in myeloma cells and development of novel drugs
| Project/Area Number |
26460720
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Medical Physics and Radiological Technology
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| Research Institution | Gunma University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 多発性骨髄腫 / マイクロPIXE / 微量元素 / ボルテゾミブ |
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| Outline of Final Research Achievements |
We introduced an in-air micro-PIXE (micro-PIXE) method in the measurement of trace elements in cultured myeloma cells and analyzed the change of trace elements before and after the treatment with bortezomib (proteasome inhibitor) and melphalan (alkylating agent). The cells were gathered on polycarbonate film with cytocentrifuge and measured with micro-PIXE. We established the micro-PIXE method to analyze trace elements in free cultured cells. Phosphate and Calcium changed by high-dose bortezomib treatment, but not by melphalan.
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| Free Research Field |
血液検査学
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