Overall evaluation of the effect of lifestyle education and treatments for delaying or preventing type 2 diabetes: A network meta-analysis

2017 Fiscal Year Final Research Report

• Project/Area Number: 26460846
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Hygiene and public health
• Research Institution: Teikyo University
• Principal Investigator: Yamaoka Kazue 帝京大学, 大学院公衆衛生学研究科, 教授 (50091038)
• Co-Investigator(Renkei-kenkyūsha): TANGO Toshiro 帝京大学, 大学院公衆衛生学研究科, 教授 (70124477) ; NEMOTO Asuka 帝京大学, 大学院公衆衛生学研究科, 講師 (20722482) ; MATSUDA Ayako 帝京大学, 医学部, 助教 (30618997)
• Project Period (FY): 2014-04-01 – 2018-03-31
• Keywords: ネットワーク・メタアナリシス / 生活習慣改善教育 / 投薬・治療 / ハイリスク / 糖尿病 / 2hPG / 多変量 / 混合効果モデル

Outline of Final Research Achievements

Type 2 diabetes (T2D) continues to increase worldwide, and effective treatment for improvement of the disease condition has been is examined.The aim of the present study was to assess the effectiveness of different types of treatments and lifestyle education across multiple outcome measures on delaying or preventing in high risk for T2DM by the network meta-analysis (NMA) with RCT.Intervention period was over 6 months and intervention to improve medication, treatment, lifestyle habits compared with the control group was targeted. The outcome variable was the change from baseline of T2D and 2hPG, and was analyzed by multivariate NMA. Analysis of 52 RCTs showed that the heterogeneity variance was larger in 2hPG than T2D, while the relationship between the them was relatively strong. The improvement of lifestyle education showed significant effect in both T2D and 2hPG.

Free Research Field

生物統計学