Forensic Toxicological Study on Excretion of Intravenously Administered Drugs into the Stomach

2016 Fiscal Year Final Research Report

• Project/Area Number: 26460893
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Legal medicine
• Research Institution: Kawasaki University of Medical Welfare
• Principal Investigator: MORIYA Fumio 川崎医療福祉大学, 医療福祉学部, 教授 (40182274)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 社会医学 / 法中毒学 / 静脈内投与薬物 / 塩基性薬物 / メタンフェタミン / 胃内排泄 / 動物実験モデル / ガスクロマトグラフ-質量分析法

Outline of Final Research Achievements

Our analytical findings on drugs in forensic autopsy cases demonstrated that: (1) basic drugs such as methamphetamine and ephedrine that are excreted into urine as unmetabolized form into urine at a large proportion appear at a higher concentration in urine than in the stomach when administered intravenously, and basic drugs that are mostly excreted into urine as metabolized form appear at a higher concentration in the stomach than in urine after intravenous administration; and (2) metabolites of a basic drug which increase gradually in blood are rapidly excreted into the stomach if they preserve basic character.
An animal experiment using rabbits demonstrated that flecainide, a basic drug, is rapidly excreted into the stomach when it is intravenously administered. We established an animal model using rats for investigating excretion patterns of methamphetamine into the stomach.

Free Research Field

医歯薬学