Study of molecular basis of motilin and growth hormone secretagogue receptor

2016 Fiscal Year Final Research Report

• Project/Area Number: 26460939
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Gastroenterology
• Research Institution: Ehime University
• Principal Investigator: Matsuura Bunzo 愛媛大学, 医学系研究科, 寄附講座教授 (80284420)
• Research Collaborator: Kawamura Tomoe 愛媛大学, 大学院生 ; Takano Akiko 愛媛大学, 職員 ; Miller Lawrence J Mayo Clinic Arizona, Professor
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: モチリン受容体 / グレリン受容体 / 受容体活性化機構 / 受容体脱感作機構 / トランスジェニックマウス

Outline of Final Research Achievements

Motilin, erythromycin and ghrelin are important endogenous regulators of gastrointestinal motor function, mediated by the class A G protein-coupled motilin receptor (MLNR) and growth hormone secretagogue receptor (GHSR). We have clarified MLNR is induced desensitization by motilin, resulting from slow recycling to cell surface, compared to macrolides such as erythromycin. We also clarified in the MLNR-TG mice gastric empty time and small intestine transit time by MLNR agonists are shorter than WT mice.

Free Research Field

消化器病学