2016 Fiscal Year Final Research Report
Prediction of drug sensitivity to gastric cancer using BH3 profiling
| Project/Area Number |
26460943
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Sapporo Medical University |
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Principal Investigator |
KAWANO YUTAKA 札幌医科大学, 医学部, 助教 (80398320)
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| Research Collaborator |
Letai Anthony ダナ・ファーバー癌研究所
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 抗癌剤感受性 / 胃癌 / BH3プロファイリング |
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| Outline of Final Research Achievements |
Drug sensitivity and BH3 profiling for seven gastric cancer cell lines were examined. BIM BH3 profiling results correlated with docetaxel sensitivity and also BAK protein expression. Patients with higher BAK protein expression in gastric cancer showed improved progression-free survival and overall survival.
BAK expression in gastric cancer is thus predictive of chemotherapeutic response to docetaxel and clinical prognosis in patients with docetaxel including chemotherapy.
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| Free Research Field |
医歯薬学
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