2016 Fiscal Year Final Research Report
Acid sphingomyelinase-derived liver macrophage inhibits growth of metastatic colon cancer in the liver.
| Project/Area Number |
26460965
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Tokyo Metropolitan Komagome Hospital (Clinical research laboratory) |
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Principal Investigator |
Yosuke Osawa 東京都立駒込病院(臨床研究室), 肝臓内科, 医長 (60447787)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 転移性肝腫瘍 / 肝線維化 / スフィンゴ脂質 / βカテニンシグナル |
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| Outline of Final Research Achievements |
Sphingolipids regulate carcinogenesis and proliferation, survival, and apoptosis of cancer cells.In this study, the involvement of ASM in liver metastasis of colon cancer was examined. ASM in the liver inhibits tumor growth through cytotoxic macrophage. Thus, targeting ASM may represent a new therapeutic strategy for treating liver metastasis of colon cancer.
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| Free Research Field |
肝臓病学
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