2016 Fiscal Year Final Research Report
Clarification of the pathogenecity and the application of therapies from biliary epithelial cells in primary biliary cholangitis
| Project/Area Number |
26461012
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
|
| Keywords | 原発性胆汁性胆管炎 / anion exchanger 2 / 疎水性胆汁酸 / IFN-g / 細胞老化 |
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| Outline of Final Research Achievements |
To address the role of AE2 in preventing PBC pathogenesis, we took advantage of our ability to isolate human BEC and autologous splenic mononuclear cells (SMC). We studied the influence of hydrophobic bile acids (GCDC), on AE2 expression in BEC and the subsequent impact on the phenotypes of BEC and local inflammatory responses. We demonstrate herein that GCDC reduces AE2 expression in BEC through induction of ROS, which enhances senescence of BEC. In addition, a reduction of AE2 levels upregulates the production of IL-6, IL-8 and CXCL10 from BEC in response to toll like receptor ligands.
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| Free Research Field |
自己免疫
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