Exploratory study of novel oxidative stress markers for early diagnosis of pulmonary hypertension

2017 Fiscal Year Final Research Report

• Project/Area Number: 26461113
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Cardiovascular medicine
• Research Institution: Nagasaki University
• Principal Investigator: IKEDA Satoshi 長崎大学, 医歯薬学総合研究科(医学系), 講師 (10336159)
• Co-Investigator(Kenkyū-buntansha): 浦田 芳重 長崎大学, 医歯薬学総合研究科(医学系), 助教 (30185087) ; 前村 浩二 長崎大学, 医歯薬学総合研究科(医学系), 教授 (90282649)
• Project Period (FY): 2014-04-01 – 2018-03-31
• Keywords: 肺高血圧症 / 酸化ストレス

Outline of Final Research Achievements

The prognosis of pulmonary arterial hypertension (PAH) is poor; therefore, early diagnosis and treatment is required. However, the useful biomarkers for the diagnosis have not been established. In the present study, we examined whether oxidative stress-related proteins, such as glutathionylated protein and PGC-1α, could be the biomarkers, because oxidative stress is involved in PAH development and progression. As a result, the expression of the two proteins did not differ between PAH model and control animal. We concluded that these proteins were not good biomarkers for the diagnosis of PAH.

Free Research Field

循環器内科学