Elucidation of the pathophysiology of intractable asthma from the view-point of aging of airway tissues and establishment of new treatment strategy

2016 Fiscal Year Final Research Report

• Project/Area Number: 26461166
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Respiratory organ internal medicine
• Research Institution: Osaka City University
• Principal Investigator: KANAZAWA Hiroshi 大阪市立大学, 大学院医学研究科, 准教授 (90332957)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 呼吸器内科学 / 難治性喘息 / 老化

Outline of Final Research Achievements

The pathophysiology of intractable asthma was clarified using a method of multifactorial and comprehensive assessment of aging of airway tissues, such as excessive aging of constitutive cells of the lung and formation of pentosidine crosslink in the extracellular matrix based on aging. In addition, from the results of this research, we determined the mechanism of irreversible airway obstruction, which is a characteristic of airway responsiveness of intractable asthma, and proposed the pathophysiologic hypothesis of asthma-COPD overlap syndrome (ACOS). Furthermore, we developed a new research field toward the goal of developing innovative and novel therapeutic methods for intractable asthma.

Free Research Field

呼吸器内科学