2016 Fiscal Year Final Research Report
Identification of novel therapeutic targets for allergic bronchopulmonary mycosis
| Project/Area Number |
26461167
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | Tokai University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | アレルギー性気管支肺真菌症 / ABPM / アスペルギルス / セリンプロテアーゼ / IL-1α |
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| Outline of Final Research Achievements |
Allergic bronchopulmonary mycosis (ABPM) is a refractory allergic airway disease characterized by a hypersensitivity reaction to fungi colonizing the airways. Previously, we reported the induction of mucin-related MUC5AC gene in the airway epithelial cells by serine protease derived from Aspergillus fumigatus extract. In this study, we conducted DNA microarray analysis of a human bronchial epithelial cell line, stimulated with serine protease derived from A. fumigatus, to identify novel therapeutic targets for ABPM. We confirmed 428 genes upregulated by serine protease, including cytokine-cytokine receptor-related genes, such as TSLP, IL-1α, and VEGF. Some of the cytokine-cytokine receptor-related genes were induced through epidermal growth factor receptor.
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| Free Research Field |
呼吸器内科学
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