Transcriptome analysis of pulmonary arterioles in interstitial pneumonia with pulmonary hypertension

2016 Fiscal Year Final Research Report

• Project/Area Number: 26461187
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Respiratory organ internal medicine
• Research Institution: Kyoto University
• Principal Investigator: Handa Tomohiro 京都大学, 医学研究科, 助教 (10432395)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 間質性肺疾患 / 肺高血圧症 / メトリックスメタロプロテアーゼ

Outline of Final Research Achievements

First, pathological grades of pulmonary arterioles in resected lungs from patients with interstitial pneumonias who underwent lung transplantation was assessed. In fibrotic areas, pulmonary arterial lesion was observed extensively, while pathological findings of pulmonary arteries were mild in less fibrotic areas. Secondary, RNA expression of matrix metalloproteinases (MMPs) was analyzed using whole lung specimen from IPF patients with and without pulmonary hypertension (PH). RNA expression of MMP-2 and MMP-9 were increased in patients with PH. In immunohistochemical analysis, their expression was mainly obserbed on lung epithelial cells, and their expression on pulmonary arterial cells were mild.

Free Research Field

呼吸器内科学