Elucidation of cognitive functions and molecular pathogenesis in Alzheimer's disease by CSF and PiB-PET

2016 Fiscal Year Final Research Report

• Project/Area Number: 26461264
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Neurology
• Research Institution: Gunma University
• Principal Investigator: Ikeda Masaki 群馬大学, 大学院医学系研究科, 准教授 (50222899)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: アルツハイマー病 / 脳アミロイドβ / 大脳皮質微小出血 / PiB-PET / 脳脊髄液 / 脳血流SPECT / 進行性失語

Outline of Final Research Achievements

All four clinical subtypes of AD significantly increased CSF ptau-181 and decrease of Aβ1-42 compared with non-demented subjects（p<0.0001）. In logopenic progressive aphasic AD (l-AD) patients group, the number of lobar cerebral microbleeds (LCMBs) significantly increased in the left hemisphere than right side, although visuospatial cognition deficit AD (v-AD) did not show such lateralities. Decreased cerebral blood flow (CBF) and glucose hypometabolism were observed in left side, which may lead to speech disturbance, especially logopenic progressive aphasia.

Free Research Field

医歯薬学