2016 Fiscal Year Final Research Report
Genes related to islet-specific autoimmune destruction and prevention of type 1 diabetes by regulating immune tolerance
| Project/Area Number |
26461349
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Metabolomics
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| Research Institution | Kindai University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | １型糖尿病 / 免疫寛容 / β細胞 |
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| Outline of Final Research Achievements |
This study aimed to clarify the mechanism of specific destruction of insulin-producing pancreatic beta cells and to prevent beta cell specific destruction. As for human study, genes related to organ specificity were clarified by association study of patients with type 1 diabetes, Graves disease and alopecia areata. Whole exome sequence analysis identified causal variant for familial, as well as sporadic type 1 diabetes in the Japanese population. As for mouse study, disruption of Mafa gene caused accelerated infiltration of lymphocytes into pancreatic islets, but suppressed spontaneous development of diabetes in the NOD mouse. Immunohistochemical staining by Foxp3 antibody suggested the involvement of a regulatory mechanism in benign insulitis.
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| Free Research Field |
糖尿病
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