Prevention of Metabolic syndrome by Apop gene regulation

2017 Fiscal Year Final Research Report

• Project/Area Number: 26461364
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Metabolomics
• Research Institution: National Institute of Fitness and Sports in Kanoya (2016-2017); Kumamoto University (2014-2015)
• Principal Investigator: Yasuda Osamu 鹿屋体育大学, スポーツ生命科学系, 教授 (00372615)
• Co-Investigator(Kenkyū-buntansha): 樂木 宏実 大阪大学, 医学系研究科, 教授 (20252679) ; 福尾 惠介 武庫川女子大学, 生活環境学部, 教授 (40156758)
• Project Period (FY): 2014-04-01 – 2018-03-31
• Keywords: ミトコンドリア

Outline of Final Research Achievements

Apop gene was originally cloned as a gene expressed in the mouse atherosclerotic plaques. Apop gene encodes a protein localized in the mitochondria of cells. The function of Apop was unclear, however, our research revealed that Apop is implicated in the regulation of mitochondrial function. Apop gene-deficient mouse showed lowered cholesterol level and reduced visceral fat tissue, suggesting the improved metabolism of fat. This study clarified that Apop gene plays an important role in the development of metabolic syndrome.

Free Research Field

血管生物学