Investigation on T cell-dependent, IgE-independent bronchoconstriction mechanism

2016 Fiscal Year Final Research Report

• Project/Area Number: 26461497
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Collagenous pathology/Allergology
• Research Institution: Clinical Research Center for Allergy and Rheumatology, National Hospital Organization, Sagamihara National Hospital
• Principal Investigator: MORI AKIO 独立行政法人国立病院機構(相模原病院臨床研究センター), 先端技術開発研究部, 部長 (80251247)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 喘息 / T細胞 / 平滑筋 / 遅発型反応 / 喘息モデル

Outline of Final Research Achievements

T cell-induced bronchoconstriction in asthma is studied in the present study. Antigen-specific T cell clones were established from PBMC obtained from asthmatic donors, and the culture supernatants of T cell clones were analyzed in terms of human bronchial smooth muscle cells-embedded collagen gels. In addition, murine antigen-specific T cell clones and murine asthma model was established to clarify immunological mechanisms of T cell-induced bronchoconstriction. Lastly, we tried to analyze guinea pig bronchial ring for pharmacological characterization of this response.

Free Research Field

アレルギー学