Elucidation of a relationship of bacteriophage to pathogenicity of Helicobacter pylori and development of eradication system to H. pylori using bacteriophage.

2016 Fiscal Year Final Research Report

• Project/Area Number: 26461504
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Infectious disease medicine
• Research Institution: Kochi University
• Principal Investigator: MATSUZAKI Shigenobu 高知大学, 教育研究部医療学系基礎医学部門, 准教授 (00190439)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: ピロリ菌 / バクテリオファージ / 除菌

Outline of Final Research Achievements

In this study, we aimed at collection of information about a bacteriophage-exclusion system (restriction-modification system) in Helicobacter pylori, to develop an effective sterilization method of drug-resistant H. pylori from the stomach using bacteriophages KHP30 and KHP40. The results indicated that H. pylori had multiple functional restriction-modification systems, suggesting strongly that the bacteriophages must be adapted to all H. pylori-possessed restriction-modification systems for effective sterilization.

Free Research Field

Microbiology