2017 Fiscal Year Final Research Report
The role of intestinal flora in the pathogenesis of biliary atresia
| Project/Area Number |
26461609
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | Osaka University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
近藤 宏樹 大阪大学, 医学系研究科, 招へい教員 (10373515)
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| Project Period (FY) |
2014-04-01 – 2018-03-31
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| Keywords | 胆道閉鎖症 / 腸内細菌叢 |
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| Outline of Final Research Achievements |
We found that in the liver from infants with biliary atresia, the expression level of beta-defensin, an antimicrobial peptide which activates innate immunity against gram-negative bacteria was upregulated compared to livers from diseased and normal controls. The expression level of its receptor, TLR4 was identified on hepatic dendritic cells.
In the rotavirus-induced murine model of biliary atresia, when we kept the colony under bactrim diet, the incidence of obstruction of extrahepatic bile duct was reduced significantly after injection of rotavirus, and a part of gram negative bacteria was decreased in the stool of mouse from the bactrim-diet colony.
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| Free Research Field |
小児肝疾患
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