Assessment for the role and function of Hic-5 in renal fibrosis for the development of treatment in pediatric chronic kidney disease

2016 Fiscal Year Final Research Report

• Project/Area Number: 26461613
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Pediatrics
• Research Institution: 独立行政法人国立病院機構四国こどもとおとなの医療センター(臨床研究部(成育)、臨床研究部(循環器)) (2015-2016); The University of Tokushima (2014)
• Principal Investigator: Kondo Shuji 独立行政法人国立病院機構四国こどもとおとなの医療センター(臨床研究部(成育)、臨, 小児科, 診療部長 (00380080)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 腎尿細管間質 / 細胞増殖 / 線維化 / 細胞接着

Outline of Final Research Achievements

Congenital anomalies of the kidney and urinary tract, genetic kidney diseases, and cystic kidney diseases are important diseases for the development of the current therapeutic strategy in pediatric chronic kidney diseases. To develop the novel treatment, the research for renal fibrosis is required. The purpose of the study is to assess the role of Hic-5 on cell injury, proliferation, and accumulation of extracellular matrix in renal fibrosis. The results we obtained are the possible relationship between Hic-5 expression and renal fibrosis in kidney diseases in the human beings and mice. In addition, we demonstrated that the growth inhibitory effect of Hic-5 might improve cell proliferation in acute phase, in contrast, induce fibrosis and sclerosis in chronic phase. A part of the results has been reported in the journal, PLoS One　(2015,10:e0122773).

Free Research Field

小児腎臓病