Analyzing glomerular renin angiotensin system with peptidomics for development of therapeutic and diagnostic methods inhibiting disease progression of chronic kidney disease

2016 Fiscal Year Final Research Report

• Project/Area Number: 26461614
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Pediatrics
• Research Institution: The University of Tokushima
• Principal Investigator: KAGAMI Shoji 徳島大学, 大学院医歯薬学研究部(医学系), 教授 (00224337)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 慢性腎臓病 / レニンアンジオテンシン系 / アンジオテンシンII / ぺプチドミクス解析 / 糸球体内皮細胞 / ACE2

Outline of Final Research Achievements

In order to explore the therapeutic and diagnostic methods inhibiting disease progression in pediatric patients with chronic kidney disease(CKD), this study focused on analyzing the glomerular renin angiotensin system related peptides with peptidomics. We found the ACE2-dependent Ang II
degradation system in glomerular mesangial cells and podocytes strongly worked in patients with CKD. Additionally, level of urinary ACE2 excretion parallels with the levels of glomerular cell proliferation as well as urinary protein excretion. Therefore, we propose that control of ACE2 expression within glomeruli may offers a new therapeutic method and measurement of urinary ACE2 may be an indicator for evaluating the severity of pediatric patients with CKD.

Free Research Field

医歯薬学