Elucidate the mechanism how Kawasaki disease vasculitis occur

2016 Fiscal Year Final Research Report

• Project/Area Number: 26461624
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Pediatrics
• Research Institution: Nippon Medical School
• Principal Investigator: Fukazawa Ryuji 日本医科大学, 医学部, 准教授 (80277566)
• Co-Investigator(Renkei-kenkyūsha): Ohno Naohito 東京薬科大学, 薬学部, 教授 (80152213)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 川崎病 / マウス血管炎 / CAWS / Nod-1 / FK565

Outline of Final Research Achievements

Kawasaki disease (KD) is systemic vasculitis mainly affected infant and its etiology is still unknown. This study tries to elucidate the mechanism how KD vasculitis is induced, using KD model mouse. We used Candida Albicans Water Soluble Fraction (CAWS) and Nod-1 ligand, FK565, to induce vasculitis. Anti-mouse IL-1βantibody attenuated the occurrence of vasculitis caused by CAWS. Together with preliminary data, IL-1βand TNF played very important roles for inducing CAWS vasculitis.　On the other hand, FK565 induced more severe vasculitis in coronary arteries, and the severity of vasculitis significantly correlated with serum IL-1βconcentration.

Free Research Field

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