Effects of psychotropic drugs on the amino acid system in the brain: psychopharmacological application of high magnetic field MRS.

2016 Fiscal Year Final Research Report

• Project/Area Number: 26461719
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Psychiatric science
• Research Institution: The University of Tokushima
• Principal Investigator: OHMORI Tetsuro 徳島大学, 大学院医歯薬学研究部(医学系), 教授 (00221135)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 精神薬理学 / 脳画像解析 / グルタミン酸 / GABA

Outline of Final Research Achievements

Glutamate (Glu) and Glutamine (Gln) were separated and quantitated for bipolar disorder patients and healthy control subjects using high magnetic field MRS. Pearson 's correlation analysis revealed a significant positive correlation between the lithium carbonate blood concentration and the Gln / Glu ratio in the left basal ganglia, the valproate blood concentration and Glu in the anterior cingulate gyrus. Considering the influence of these drugs, the ratio of Gln / Glu was increased in the anterior cingulate gyrus in patients with bipolar disorder. The separation and quantification of GABA was also performed, but no clear drug effect was observed.

Free Research Field

精神神経科学