An intermediate phenotype study of clinical responses of obsessive-compulsive disorder by using high resolution MRS and NIRS

2016 Fiscal Year Final Research Report

• Project/Area Number: 26461720
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Psychiatric science
• Research Institution: The University of Tokushima
• Principal Investigator: SUMITANI Satsuki 徳島大学, 大学院医歯薬学研究部(総合支援), 教授 (90346594)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 強迫性障害 / 薬物応答遺伝子 / 中間表現型 / GWAS / MRS / NIRS / SSRI / 非定型抗精神病薬

Outline of Final Research Achievements

We studied to find genetic factors involved in clinical responses of obsessive-compulsive disorder (OCD) by using high resolusion proton magnetic resonance spectroscopy (MRS) and multichannel near infrared spectroscopy (NIRS). While we failed to detect specific genetic variants associated with clinical responses to SSRI or to SSRI with an atypical antipsychotic at genome-wide levels of significance, we identified 8 enriched pathways for the SSRI treatment response and 5 enriched pathways for the treatment response to SSRI with an antipsychotic medication. Moreover we found responders to SSRI showed different activation during the Stroop task compared to responders to SSRIs with antipsychotics by using NIRS. Our results may provide novel insight to predict clinical response in OCD patients.

Free Research Field

医歯薬学