Impairments in social bonding by PTSD

2016 Fiscal Year Final Research Report

• Project/Area Number: 26461734
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Psychiatric science
• Research Institution: Gunma University
• Principal Investigator: Mitsui Shinichi 群馬大学, 大学院保健学研究科, 教授 (20295661)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: プレリーハタネズミ / pair bonding / オキシトシン / セロトニン

Outline of Final Research Achievements

There are some reports indicating that post-tramatic stress disorder (PTSD) disrupt the social relationship between intimates. To understand the neuronal mechanisms of such phenominon, we have investigated the effect of traumatic stress on social behaviors and neuronal responses in monogamous prairie voles. Traumatic stress decreased the oxytosin-immunoreactivity at the supraoptic nucleus of thy hypothalamus and impaired the fomotion of pair bonding. The inhibitory effect by a traumatic stress was prevented by oral administration of a selective serotonin reuptake inhibitor.
Our results have revealed the impairment of social behviors and neuronal circuits caused by PTSD and will give a basic knowledge to develop novel treatment of PTSD.

Free Research Field

神経科学