2016 Fiscal Year Final Research Report
Predicting treatment effect and prognosis by using IVIM
| Project/Area Number |
26461831
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | Sapporo Medical University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | MRI / DWI / 腫瘍 / 治療効果 / 予後 |
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| Outline of Final Research Achievements |
In total, 28 patients with head and neck cancer who were treated with (chemo)radiotherapy were enrolled in the present study. However, 8 patients were excluded due to poor image quality and/or inadequate clinical data. Further, patients with nasopharyngeal cancer were excluded because its D is lower and sensitive to chemoradiotherapy. Finally, 10 patients were statistically analyzed.
The pre-treatment D value for 6 patients without recurrence was 0.640±0.168 mm2/s and that for 4 ones with recurrence was 0.921±0.204 mm2/s and statistically significant difference was observed (p<0.05). The ratio of D value increase at 10Gy was 0.350±0.533 without recurrence and 0.04±0.174 with recurrence but statistical significance was not observed. F(perfusion fraction) and D*(perfusion) derived from IVIM method show wide variation. Signal intensity at b=25 s/mm2 was lower than that at b=50 s/mm2 in some cases. Thus, F and D* were not analyzed.
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| Free Research Field |
放射線診断
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