Cognitive impairment and MRI of long-term survivors of pediatric cancer

2017 Fiscal Year Final Research Report

• Project/Area Number: 26461877
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Radiation science
• Research Institution: Tohoku University
• Principal Investigator: MUGIKURA Shunji 東北大学, 大学病院, 准教授 (20375017)
• Co-Investigator(Kenkyū-buntansha): 神宮 啓一 東北大学, 医学(系)研究科(研究院), その他 (00451592) ; 力石 健 東北大学, 大学病院, 助教 (40400379) ; 高橋 昭喜 東北大学, 医学系研究科, 名誉教授 (80148874)
• Project Period (FY): 2014-04-01 – 2018-03-31
• Keywords: MRI / 認知機能障害 / 脳腫瘍 / 小児がん / 放射線治療

Outline of Final Research Achievements

We sought to determine effects of radiation field size and dose on the extent of developing cavernous malformations in long-term survivors of pediatric cancer.The study involved 34 patients with a history of intracranial germ cell tumors treated with either whole-brain or reduced-field irradiation and undergoing MRI with a mean follow-up of 18.5 years. A total of 235 cavernous malformation lesions were observed in 32 of 34 patients. The mean number of lesions was 2.3 times as high in the whole-brain group as in the reduced-field group. The number of lesions in high-dose fields was significantly larger than in low-dose or untreated fields. Radiation field size and dose were positively associated with the number of cavernous malformations developed. Cavernous malformations can be used as a surrogate marker for microvascular injury following intracranial irradiation in long-term cancer survivors.

Free Research Field

放射線医学