2017 Fiscal Year Final Research Report
Biological Effects (DNA damege and repair) of Particle Radiation emitted by Bron Neutron Capture Reaction
| Project/Area Number |
26461884
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | Kyoto University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
木梨 友子 京都大学, 原子炉実験所, 准教授 (80252534)
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| Project Period (FY) |
2014-04-01 – 2018-03-31
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| Keywords | BNCT / ホウ素中性子捕捉療法 / 分割照射 / p53 / テモゾロミド / エネルギースペクトル / 細胞生存率 / DNA二重鎖切断 |
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| Outline of Final Research Achievements |
The effects of 1) fractionated irradiation, 2) genetic background of tumor cells, 3) co-existence of anti-cancer drug (Temozolomide), 4) energy spectrum of neutron beam, on the cell survival and the induction of DNA double strand breaks were investigated in vitro culture systems using human glioblastoma cell lines and Chinese hamster ovary cell line (CHO).
The fractionation of irradiation and mutation of p53 of glioblastoma cells modified the cell survivals and the induction of DNA-dsb. The extent of the effects was more remarkable in gamma-ray irradiation than neutron irradiation. The co-existence of Temozolomide during the irradiation period decreased the cell survival synergistically in the neutron irradiation. The neutron energy spectrum did not affect so much the cell survivals and DNA-dsb induction.
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| Free Research Field |
放射線管理学、放射線生物学、環境毒性学
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