2016 Fiscal Year Final Research Report
Development of radiosensitizers based on antitumor/molecular targeted drugs modified by acetylglucose
| Project/Area Number |
26461891
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | The University of Tokushima |
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Principal Investigator |
Uto Yoshihiro 徳島大学, 大学院生物資源産業学研究部, 教授 (20304553)
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| Co-Investigator(Renkei-kenkyūsha) |
ENDO YOSHIO 金沢大学, がん進展制御研究所, 准教授 (30211783)
TOMINAGA MASAHIDE 徳島大学, 大学院医歯薬学研究部, 助教 (90437632)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 放射線増感剤 |
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| Outline of Final Research Achievements |
The aim of this study is that development of clinical usage radiosensitizers based on acetylglucose-modified antitumor and molecular targeted drug using a tumor cell and a tumor-bearing chicken egg model. In this study, we succeeded in develop of new radiosensitizer UTX-103 which modified acetylglucose to the Gefitinib as an antitumor agent which inhibited the tyrosine kinase of the epidermal growth factor receptor selectively.
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| Free Research Field |
放射線腫瘍学
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