Optimal immunosuppressive therapy after living liver transplantation in adult

2016 Fiscal Year Final Research Report

• Project/Area Number: 26461929
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: General surgery
• Research Institution: Tokyo Women's Medical University
• Principal Investigator: Ogata Satoshi 東京女子医科大学, 医学部, 助教 (40444583)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 生体肝移植 / 免疫モニタリング / 免疫抑制剤

Outline of Final Research Achievements

Infection or rejection following living liver transplantation often causes critical liver dysfunction with insufficient hepatic capacity in the early postoperative period. Therefore, immunosuppressive induction therapy in living liver transplantation requires more strict postoperative management than whole liver transplantation. We attempted to reduce complications by using immunosuppressive induction therapy with tacrolimus, methylprednisolone and MMF after liver transplantation, in particular using lower dose tacrolimus. As a result, the incidence of rejection was acceptable, establishing a protocol that is less than that of renal dysfunction, postoperative glucose tolerance, which is a side effect of calcineurin inhibitor.

Free Research Field

肝胆膵外科、肝臓移植外科