2016 Fiscal Year Final Research Report
Oxidative stress signaling as the molecular mechanism of chemo-resistance in esophageal cancer
| Project/Area Number |
26461971
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Niigata University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
KOMATSU Masaaki 新潟大学, 医歯学系, 教授 (90356254)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 食道外科学 / 食道癌 / 術前補助化学療法 / 酸化ストレス |
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| Outline of Final Research Achievements |
We sought to elucidate the molecular mechanism of chemo-resistance in esophageal cancer from the viewpoint of oxidative stress signaling. In esophageal cancer cells, expression of NQO1, a downstream molecule of the pathway, had no significant association with histological response to preoperative chemotherapy but was an independent unfavorable prognostic factor. In addition, NQO1 expression had no significant correlation with expression of Nrf2, although it is a central molecule of the pathway and regulates NQO1 expression under physiological conditions. On the other hand, NQO1 expression in nontumorous squamous epithelium had significant association with clinical response to preoperative chemotherapy and was an independent favorable prognostic factor. NQO1 expression in nontumorous squamous epithelium could be a promising biomarker to predict treatment outcomes after preoperative chemotherapy followed by esophagectomy.
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| Free Research Field |
消化器外科学
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